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备孕及孕早期（孕12周前）每日补充400-800μg叶酸，需至少提前1-3个月开始服用，因为叶酸需要持续摄入使体内红细胞叶酸浓度达到预防神经管缺陷的有效水平，临时突击补充无效

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叶酸补充剂category

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Unverified备孕补充叶酸的标准路径：普通人群→孕前3个月起每日0.4-0.8mg普通叶酸→持续至孕12周（或整个孕期用复合制剂）；有高危史→就医评估→按需4mg处方剂量；反复流产/已知MTHFR变异→选活性甲基叶酸83% similar

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