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ConceptCryo-EM

Cryo-Electron Microscopy

An experimental method for determining protein structures in which samples are rapidly frozen and imaged with an electron beam for three-dimensional reconstruction. In recent years it has become a mainstream technique owing to a revolution in resolution.

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Oct 12

Obtaining a protein structure requires expensive experiments (such as cryo-electron microscopy and X-ray crystallography), and the cost and speed of data generation constitute a fundamental bottleneck for the development of biological AI.

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Oct 12

Cryo-electron microscopy and X-ray crystallography usually require weeks to months to resolve a protein structure, and are not applicable to all proteins.

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