Enhancer
A non-coding DNA regulatory element that can recruit transcription factors over long distances and activate the promoter of a target gene, determining the tissue specificity and spatiotemporal patterns of gene expression.
Timeline (last 90 days)
Distal enhancers contact target promoters through chromatin loops, and the motor protein cohesin extrudes DNA to form dynamic loops, building transcription hubs.
Even if an enhancer and a promoter are separated by hundreds of thousands of bases in linear sequence, they may be physically proximate due to three-dimensional folding, thereby driving gene transcription.
All Facts (2)
Distal enhancers contact target promoters through chromatin loops, and the motor protein cohesin extrudes DNA to form dynamic loops, building transcription hubs.
50%UnverifiedEven if an enhancer and a promoter are separated by hundreds of thousands of bases in linear sequence, they may be physically proximate due to three-dimensional folding, thereby driving gene transcription.
50%