Receptor-ligand interaction
The molecular basis of cell-cell communication, referring to the process in which a ligand secreted by one cell specifically binds to a receptor on the surface of a target cell and triggers downstream signaling. It is the core evidence used by AI to infer cell-cell communication links.
Timeline (last 90 days)
This AI method constructs latent communication networks by analyzing the expression profiles of cell surface receptors and secreted signaling molecules, and infers the communication links that play key roles in tissue formation, enabling data-driven discovery of previously unrecognized communication mechanisms rather than being limited to known signaling pathways.
Intercellular communication at the molecular level is mainly achieved through receptor-ligand pairing: one cell secretes a ligand, and a receptor on the surface of another cell recognizes and binds that ligand, triggering a downstream signaling cascade; classic examples include the Wnt, Notch, and TGF-β signaling pathways.
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This AI method constructs latent communication networks by analyzing the expression profiles of cell surface receptors and secreted signaling molecules, and infers the communication links that play key roles in tissue formation, enabling data-driven discovery of previously unrecognized communication mechanisms rather than being limited to known signaling pathways.
50%UnverifiedIntercellular communication at the molecular level is mainly achieved through receptor-ligand pairing: one cell secretes a ligand, and a receptor on the surface of another cell recognizes and binds that ligand, triggering a downstream signaling cascade; classic examples include the Wnt, Notch, and TGF-β signaling pathways.
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