RFD4
A diffusion model for protein structure generation based on RoseTTAFold Diffusion, used to generate foldable protein backbones from noise. It is a new iteration in the RFD series.
Timeline (last 90 days)
RFD4 is a new version on the RoseTTAFold Diffusion (RFD) line of protein structure generative diffusion models, responsible for generating foldable protein backbones from noise.
The pipeline combining RFD4 and Proteina is: RFD4 provides the generation prior at the structure level, Proteina provides the modeling capability at the sequence level, and the reward model screens and guides candidates during inference; the authors call this pipeline reward-guided inference-time search.
The RFD4-Proteina method shifts the bottleneck of the protein design workflow from training to the quality of the reward function definition.
All Facts (3)
RFD4 is a new version on the RoseTTAFold Diffusion (RFD) line of protein structure generative diffusion models, responsible for generating foldable protein backbones from noise.
50%UnverifiedThe pipeline combining RFD4 and Proteina is: RFD4 provides the generation prior at the structure level, Proteina provides the modeling capability at the sequence level, and the reward model screens and guides candidates during inference; the authors call this pipeline reward-guided inference-time search.
50%UnverifiedThe RFD4-Proteina method shifts the bottleneck of the protein design workflow from training to the quality of the reward function definition.
50%