SNP
Single Nucleotide Polymorphism, referring to variation at a single base in the genome. After whole-genome sequencing and alignment, SNP differences are tallied to determine the phylogenetic relationships among strains.
Timeline (last 90 days)
SNP differences are a common metric in genomic epidemiology for judging strain relatedness, and public health practice often sets thresholds (such as ≤2 or ≤5 SNPs) to determine a match, but the threshold depends on factors such as pathogen mutation rate and is not a universal constant.
An SNP match supports association but does not alone prove causation, and still needs to be interpreted jointly with time, place and supply chain evidence.
SNPs typically refer to common variants with a frequency exceeding 1% in a population, whereas SNVs encompass all single-base substitutions including rare mutations.
All Facts (3)
SNP differences are a common metric in genomic epidemiology for judging strain relatedness, and public health practice often sets thresholds (such as ≤2 or ≤5 SNPs) to determine a match, but the threshold depends on factors such as pathogen mutation rate and is not a universal constant.
50%UnverifiedAn SNP match supports association but does not alone prove causation, and still needs to be interpreted jointly with time, place and supply chain evidence.
50%UnverifiedSNPs typically refer to common variants with a frequency exceeding 1% in a population, whereas SNVs encompass all single-base substitutions including rare mutations.
50%