Concepttumorigenic risk
Tumorigenic Risk
The risk of tumor formation in iPSC technology arising from reactivation of proto-oncogenes such as c-Myc and from residual undifferentiated cells. It is a major safety obstacle to the clinical translation of cell therapies.
Timeline (last 90 days)
Oct 13
The c-Myc used in the reprogramming process is a proto-oncogene, and its reactivation may promote abnormal cell proliferation, posing a tumorigenic risk.
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