Unverified50% confidenceFactExact time
Henri B. Kagan revealed a nonlinear effect: under certain conditions, a tiny difference in catalyst chirality can have a huge impact on the proportion of enantiomers in the product.
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10/12/2026
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UnverifiedIn 1986, Kagan published findings on nonlinear effects, discovering that product ratios do not change linearly with the catalyst but follow a curve, which can significantly increase the proportion of the target mirror-image molecule.74% similarUnverifiedIn 1986, Kagan reported that in certain catalytic systems, the relationship between catalyst ee and product ee is nonlinear, that is, a positive nonlinear effect or a negative nonlinear effect.72% similarUnverifiedKagan confirmed the positive nonlinear effect model through experiments such as the Sharpless oxidation reaction, with the measured curves clearly deviating from the expected straight line.69% similarUnverifiedKagan and Soai were recognized for the discovery of nonlinear effects and autocatalysis in asymmetric organic synthesis.68% similarUnverifiedKagan challenged the dogma that the ratio of product enantiomers is linearly related to the ratio of the catalyst, proposing that two or more chiral ligands can simultaneously bind to the metal center of a catalyst.68% similar
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