Unverified50% confidenceFactExact time
Designability is a commonly used evaluation criterion in generative protein design: the generated backbone is fed into an independent sequence design model (such as ProteinMPNN), and the predicted sequence is then refolded using a structure prediction tool (such as ESMFold or AlphaFold); if the predicted structure is highly consistent with the original backbone (usually judged by an scRMSD threshold), the backbone is considered designable.
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10/14/2026
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