Unverified50% confidenceFactExact time
A synthetic compound designed by DrugHarness achieved a cellular IC50 of 14.19 nM, a 2.64-fold potency improvement over the best input reference molecule, with activity comparable to selected compounds designed by two senior medicinal chemists.
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50%
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Long-term
Relevance
10/19/2026
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Related Claims
UnverifiedCellular IC50 refers to the compound concentration required to inhibit kinase activity or related signaling by 50% at the cellular level; lower values indicate stronger potency, and 14.19 nM falls in the sub-micromolar high-activity range.74% similarUnverifiedThe Soai reaction was first reported in 1995, using an addition reaction between pyridinecarboxaldehyde and an organozinc reagent, in which the alcohol product can catalyze the next round of same-chirality product formation with extremely high efficiency.62% similarUnverifiedMany drug molecules exist in two chiral structures that are mirror images of each other, and traditional chemical synthesis methods often produce a mixture of the two chiral molecules, one of which may have therapeutic effect while the other may be ineffective or even harmful.60% similar
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