Unverified50% confidenceFactExact time
The Soai reaction was first reported in 1995, using an addition reaction between pyridinecarboxaldehyde and an organozinc reagent, in which the alcohol product can catalyze the next round of same-chirality product formation with extremely high efficiency.
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10/8/2026
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UnverifiedThe Soai reaction is an addition reaction between pyridine-5-carbaldehyde and diisopropylzinc, with an amplification factor as high as 630,000-fold; the product is a chiral secondary alcohol that can catalyze the next round of reaction, forming an autocatalytic cycle.77% similarUnverifiedThe Soai reaction uses pyrimidinyl aldehyde as the substrate to react with a dialkylzinc reagent to produce a chiral alcohol, which itself is the catalyst for the reaction, and its amplification mechanism is related to the fact that homochiral dimers are far more active than heterochiral dimers.72% similarUnverifiedKenso Soai discovered and elucidated the "Soai reaction," an asymmetric autocatalytic reaction catalyzed by small organic molecules.63% similar
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