Unverified50% confidenceFactExact time
The capability for protein sequence–structure joint design is relevant to downstream applications such as drug discovery, antibody engineering, and enzyme design.
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9/11/2026
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UnverifiedCo-folding refers to simultaneously predicting the three-dimensional structures of a protein and a ligand and their binding mode, allowing the protein and ligand to mutually adapt (induced fit effect).69% similarUnverified传统分子对接方法（如AutoDock、Glide）通常假设蛋白质构象固定，仅对配体做柔性搜索67% similarUnverifiedAlphaFold solved the protein folding problem that had puzzled the biology community for 50 years—namely, predicting the three-dimensional structure of a protein from its amino acid sequence—through deep learning technology.66% similarUnverifiedProtein function is jointly determined by the interaction between amino acid sequences and three-dimensional spatial structures.66% similarUnverifiedTraditional protein design methods maintain a design success rate of 5–10%63% similar
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