Verified75% confidenceFactExact time
Protein function is jointly determined by the interaction between amino acid sequences and three-dimensional spatial structures.
3
Sources
75%
Confidence
Long-term
Relevance
9/11/2026
First Seen
Sources
Related Entities
Related Claims
UnverifiedModifications to amino acid sequences may affect whether a protein can fold correctly and perform functions such as catalysis, binding, or signal transduction.77% similarVerified1972 Nobel laureate Christian Anfinsen proposed that the amino acid sequence of a protein determines its three-dimensional structure.74% similarUnverifiedProtein inverse folding refers to designing amino acid sequences that fold into a given three-dimensional backbone structure; ProteinMPNN and ESM-IF are representative tools.74% similarVerifiedCo-folding refers to simultaneously predicting the three-dimensional structures of a protein and a ligand and their binding mode, allowing the protein and ligand to mutually adapt (induced fit effect).74% similarUnverifiedProteins are composed of 20 types of amino acids connected in a specific order, and the linear sequence spontaneously folds into a specific three-dimensional conformation in a cellular environment.73% similar
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