Unverified50% confidenceFactExact time
In 1953, Charles Frank proposed a model specifying three conditions: the reaction requires a chiral catalyst, the generation of one mirror-image molecule is enhanced while the other is suppressed, and the reaction can generate its own catalyst (autocatalysis).
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10/11/2026
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UnverifiedThe Frank model demonstrates that if a chiral molecule can catalyze its own formation while inhibiting the formation of its mirror-image molecule, even an extremely minute initial difference in the ratio of the two chiral molecules will ultimately evolve into an almost purely single-chirality outcome.72% similarUnverified艾伦·图灵在1952年论文《形态发生的化学基础》中首次从数学角度描述生物体表面斑纹的形成机制，提出反应扩散系统理论68% similarUnverifiedKagan challenged the dogma that the ratio of product enantiomers is linearly related to the ratio of the catalyst, proposing that two or more chiral ligands can simultaneously bind to the metal center of a catalyst.64% similarUnverifiedIn 1995, Soai Kenso published a breakthrough experiment using pyrimidyl alcohol to achieve asymmetric autocatalysis, in which the starting enantiomeric excess of one isomer was only 2%, and by the end of the reaction the enantiomeric excess had risen to 87%.63% similarUnverifiedThe 1953 Miller–Urey experiment successfully synthesized amino acids in the laboratory by simulating primitive atmospheric conditions, providing experimental support for the primordial soup hypothesis.62% similar
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