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In 1986, Kagan's team reported three reactions and found that the relationship between catalyst purity and product purity was not linear but curved—sometimes a catalyst of only half purity could produce a product of far higher purity, which is known as the nonlinear effect.
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10/12/2026
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UnverifiedIn 1986, Kagan published findings on nonlinear effects, discovering that product ratios do not change linearly with the catalyst but follow a curve, which can significantly increase the proportion of the target mirror-image molecule.74% similarUnverifiedIn 1986, Kagan reported that in certain catalytic systems, the relationship between catalyst ee and product ee is nonlinear, that is, a positive nonlinear effect or a negative nonlinear effect.71% similarUnverifiedIn 1986, Henry B. Cogon revealed the nonlinear effect, demonstrating that an initial deviation so small it is almost negligible can be amplified in the reaction far beyond expectations, and that product purity can be higher than catalyst purity.70% similarUnverifiedIn 1995, Soai Kenso published a breakthrough experiment using pyrimidyl alcohol to achieve asymmetric autocatalysis, in which the starting enantiomeric excess of one isomer was only 2%, and by the end of the reaction the enantiomeric excess had risen to 87%.70% similarUnverifiedHenri B. Kagan revealed a nonlinear effect: under certain conditions, a tiny difference in catalyst chirality can have a huge impact on the proportion of enantiomers in the product.70% similar
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