Amyloid Hypothesis
One of the leading theories in Alzheimer's disease research, holding that plaques formed by the abnormal aggregation of beta-amyloid (Aβ) in the brain are the initiating factor of the disease, and that clearing Aβ is regarded as the key to treatment.
Timeline (last 90 days)
The amyloid hypothesis has been the dominant theory in Alzheimer's drug development over the past nearly three decades.
A key paper published in Nature in 2006 supporting the amyloid hypothesis was later identified as suspected of data fabrication, influencing the direction of research and billions of dollars in drug development investment over the following decade-plus
All Facts (2)
The amyloid hypothesis has been the dominant theory in Alzheimer's drug development over the past nearly three decades.
50%UnverifiedA key paper published in Nature in 2006 supporting the amyloid hypothesis was later identified as suspected of data fabrication, influencing the direction of research and billions of dollars in drug development investment over the following decade-plus
50%