CADD
Combined Annotation Dependent Depletion. A widely used genomic variant functional prediction scoring tool that evaluates and scores the deleteriousness of DNA variants by integrating multiple annotation features.
Timeline (last 90 days)
Earlier functional prediction tools such as CADD, PolyPhen-2, and SIFT can also score large numbers of variants, but AlphaGenome has the ability to predict multi-dimensional molecular phenotypes from sequence.
The CADD score, released in 2014, integrates 63 different annotation features and was the first to simultaneously evaluate variants in both coding and non-coding regions.
All Facts (2)
Earlier functional prediction tools such as CADD, PolyPhen-2, and SIFT can also score large numbers of variants, but AlphaGenome has the ability to predict multi-dimensional molecular phenotypes from sequence.
50%UnverifiedThe CADD score, released in 2014, integrates 63 different annotation features and was the first to simultaneously evaluate variants in both coding and non-coding regions.
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