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BenchmarkCritical Assessment of protein Structure Prediction 14

CASP14

The 14th Critical Assessment of Protein Structure Prediction competition, held in 2020. CASP is the most authoritative biennial international benchmark for protein structure prediction in the bioinformatics field. AlphaFold2 achieved a landmark result at this competition, demonstrating accuracy that approached experimental methods.

Core Facts

Timeline (last 90 days)

Oct 16

AlphaFold was developed by DeepMind and achieved accuracy comparable to experimental methods in the 2020 CASP14 competition, and is regarded as one of the most significant breakthroughs in structural biology in fifty years.

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Oct 12

AlphaFold2 achieved a median score of about 90 GDT-TS in the 2020 CASP14 assessment, far exceeding the previous level of about 60 points.

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Sep 11

AlphaFold2 won CASP14 with a median GDT score of 92.4, approaching the level of experimental methods such as X-ray crystallography and cryo-electron microscopy.

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Sep 10

AlphaFold2 solved the protein structure prediction problem in 2020, achieving experimental-level prediction accuracy at the CASP14 competition with a median GDT score exceeding 92.

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