Cohesin
A ring-shaped multiprotein complex with motor activity that extrudes along DNA to form chromatin loops, serving as the core executor of three-dimensional genome organization and loop extrusion.
Timeline (last 90 days)
Distal enhancers contact target promoters through chromatin loops, and the motor protein cohesin extrudes DNA to form dynamic loops, building transcription hubs.
The loop extrusion model holds that the cohesin ring extrudes along DNA at a rate of about 0.5-1 kb per second until it stalls upon encountering a CTCF binding site in the correct orientation.
All Facts (2)
Distal enhancers contact target promoters through chromatin loops, and the motor protein cohesin extrudes DNA to form dynamic loops, building transcription hubs.
50%UnverifiedThe loop extrusion model holds that the cohesin ring extrudes along DNA at a rate of about 0.5-1 kb per second until it stalls upon encountering a CTCF binding site in the correct orientation.
50%