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Concept

CTCF

CCCTC-binding factor, a zinc finger protein that serves as a key regulatory protein acting as a chromatin insulator and boundary of topologically associating domains.

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Oct 19

The loop extrusion model holds that the cohesin ring extrudes along DNA at a rate of about 0.5-1 kb per second until it stalls upon encountering a CTCF binding site in the correct orientation.

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