Frank Model

A chemical evolution model proposed by Frank in 1953 that conjectured chiral autocatalysis as a possible mechanism for the origin of biological homochirality. The model combines autocatalytic amplification with mutual inhibition between enantiomers, allowing a small initial imbalance to develop into a nearly pure chiral state. It was later supported experimentally by the Soai reaction and remains a foundational reference in theories of chiral symmetry breaking.