[KongchangAI]
Concept基因集富集分析

GSEA

Gene Set Enrichment Analysis, a statistical method used to determine whether a predefined gene set shows differential expression between two biological states.

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Oct 30

In the demonstration, the WorkBuddy agent used a Skill (skill package) written by "Shenxin Self-Study Network" to execute in sequence according to a preset workflow: data merging and batch correction, differential analysis and visualization, WGCNA co-expression analysis, intersection gene acquisition, GO/KEGG enrichment, PPI network construction, LASSO/SVM/random forest/Boruta feature gene screening, feature gene validation and visualization, GSEA/GSVA and immune analysis, ceRNA/transcription factor regulatory network construction, and drug sensitivity analysis, and generated a structured report.

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Aug 23

GSEA由Broad研究所的Subramanian等人于2005年在PNAS上首次提出

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Aug 23

GSEA不依赖预先筛选的差异基因,而是对全部基因按表达变化排序后检测特定基因集是否显著富集

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