Hemoglobin-Based Oxygen Carrier
A hemoglobin-based oxygen carrier (HBOC) is a blood substitute made from chemically modified cell-free hemoglobin. It can be freeze-dried and rapidly reconstituted. Modifications such as cross-linking, polymerization, or PEGylation extend its half-life and reduce renal toxicity.
Timeline (last 90 days)
The main current technical routes for artificial blood include hemoglobin-based oxygen carriers, perfluorocarbon emulsions, and stem-cell-cultured red blood cells.
Hemoglobin-based oxygen carriers (HBOCs) are blood substitutes made from free hemoglobin after chemical modification, using chemical modification methods such as cross-linking, polymerization or PEGylation to extend half-life and reduce toxic side effects.
Early HBOC products such as HemAssist and PolyPheme showed serious adverse events including vasoconstriction and myocardial infarction in clinical trials, mainly because free hemoglobin scavenges nitric oxide, causing abnormal vascular tone.
All Facts (3)
The main current technical routes for artificial blood include hemoglobin-based oxygen carriers, perfluorocarbon emulsions, and stem-cell-cultured red blood cells.
50%UnverifiedHemoglobin-based oxygen carriers (HBOCs) are blood substitutes made from free hemoglobin after chemical modification, using chemical modification methods such as cross-linking, polymerization or PEGylation to extend half-life and reduce toxic side effects.
50%UnverifiedEarly HBOC products such as HemAssist and PolyPheme showed serious adverse events including vasoconstriction and myocardial infarction in clinical trials, mainly because free hemoglobin scavenges nitric oxide, causing abnormal vascular tone.
50%