Unverified50% confidenceFactExact time
Kagan found that in certain asymmetric catalytic systems, using a catalyst with a low ee value can nonetheless yield a product with a high ee value, and even a positive nonlinear effect occurs, in which a small amount of chiral catalyst can induce a large amount of chiral product.
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Long-term
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10/12/2026
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UnverifiedKagan proposed that two or more chiral ligands can simultaneously bind to a metal to form a catalyst, and when the activity of the heterochiral complex is far lower than that of other types, the ratio of product enantiomers will exceed the ratio of the catalyst itself—a phenomenon known as the positive nonlinear effect.75% similarPartially VerifiedSoai developed asymmetric autocatalytic reactions, in which the reaction product itself acts as its own catalyst, capable of amplifying a tiny chiral bias starting from achiral raw materials.69% similarUnverifiedThe positive nonlinear effect means that high-purity products can be obtained without preparing the catalyst to extremely high purity, thereby significantly reducing production costs.63% similarUnverifiedTraditional asymmetric synthesis often requires expensive chiral ligands or enzyme catalysts, and its efficiency is limited by the catalyst's turnover number and selectivity.61% similarUnverifiedThe chemical essence of the nonlinear effect lies in the fact that chiral catalyst molecules can form dimers or multimers, and different aggregation states have completely different catalytic activity and chiral selectivity.61% similar
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