Unverified60% confidenceFactExact time
The Soai reaction demonstrates an autocatalytic phenomenon in which the reaction product itself can act as a catalyst to promote its own formation, and an initial ee value of only 2% can climb to above 87% after multiple rounds of autocatalytic cycles.
2
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60%
Confidence
Long-term
Relevance
10/12/2026
First Seen
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Related Claims
Partially VerifiedSoai developed asymmetric autocatalytic reactions, in which the reaction product itself acts as its own catalyst, capable of amplifying a tiny chiral bias starting from achiral raw materials.76% similarUnverifiedKenso Soai discovered and elucidated the "Soai reaction," an asymmetric autocatalytic reaction catalyzed by small organic molecules.70% similarUnverifiedThe Soai reaction is an addition reaction between pyridine-5-carbaldehyde and diisopropylzinc, with an amplification factor as high as 630,000-fold; the product is a chiral secondary alcohol that can catalyze the next round of reaction, forming an autocatalytic cycle.69% similarUnverifiedThe Soai reaction uses pyrimidinyl aldehyde as the substrate to react with a dialkylzinc reagent to produce a chiral alcohol, which itself is the catalyst for the reaction, and its amplification mechanism is related to the fact that homochiral dimers are far more active than heterochiral dimers.68% similarUnverifiedKagan found that in certain asymmetric catalytic systems, using a catalyst with a low ee value can nonetheless yield a product with a high ee value, and even a positive nonlinear effect occurs, in which a small amount of chiral catalyst can induce a large amount of chiral product.64% similar
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