Verified80% confidenceFactExact time
The Soai reaction uses pyrimidinyl aldehyde as the substrate to react with a dialkylzinc reagent to produce a chiral alcohol, which itself is the catalyst for the reaction, and its amplification mechanism is related to the fact that homochiral dimers are far more active than heterochiral dimers.
6
Sources
80%
Confidence
Long-term
Relevance
10/8/2026
First Seen
Sources
Related Entities
Related Claims
UnverifiedIn 1995, Soai and his colleagues reported a landmark asymmetric autocatalytic reaction: the addition of dialkylzinc reagents to pyrimidine-containing aldehydes, producing a chiral alcohol that can promote the reaction.76% similarUnverifiedKenso Soai discovered and elucidated the "Soai reaction," an asymmetric autocatalytic reaction catalyzed by small organic molecules.76% similarUnverifiedThe Soai reaction is an addition reaction between pyridine-5-carbaldehyde and diisopropylzinc, with an amplification factor as high as 630,000-fold; the product is a chiral secondary alcohol that can catalyze the next round of reaction, forming an autocatalytic cycle.75% similarUnverifiedThe Soai reaction was first reported in 1995, using an addition reaction between pyridinecarboxaldehyde and an organozinc reagent, in which the alcohol product can catalyze the next round of same-chirality product formation with extremely high efficiency.72% similarUnverifiedThe Soai reaction demonstrates an autocatalytic phenomenon in which the reaction product itself can act as a catalyst to promote its own formation, and an initial ee value of only 2% can climb to above 87% after multiple rounds of autocatalytic cycles.68% similar
Cite This Claim
Stable URI
https://kongchang.com/claim/989677API
curl https://kongchang.com/api/v1/knowledge/claims/989677MCP
get_claim(id=989677)