Unverified50% confidenceFactExact time
Protein inverse folding refers to designing amino acid sequences that fold into a given three-dimensional backbone structure; ProteinMPNN and ESM-IF are representative tools.
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9/28/2026
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VerifiedCo-folding refers to simultaneously predicting the three-dimensional structures of a protein and a ligand and their binding mode, allowing the protein and ligand to mutually adapt (induced fit effect).77% similarUnverifiedProtein function is jointly determined by the interaction between amino acid sequences and three-dimensional spatial structures.74% similarUnverifiedProteinMPNN uses a message-passing neural network to predict the optimal amino acid sequence given a backbone structure, solving the inverse folding problem.69% similarUnverified传统分子对接方法（如AutoDock、Glide）通常假设蛋白质构象固定，仅对配体做柔性搜索67% similarVerified1972 Nobel laureate Christian Anfinsen proposed that the amino acid sequence of a protein determines its three-dimensional structure.66% similar
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