Unverified50% confidenceFactExact time
Modifications to amino acid sequences may affect whether a protein can fold correctly and perform functions such as catalysis, binding, or signal transduction.
1
Sources
50%
Confidence
Long-term
Relevance
9/30/2026
First Seen
Sources
Related Entities
Related Claims
UnverifiedProtein function is jointly determined by the interaction between amino acid sequences and three-dimensional spatial structures.77% similarUnverifiedProtein variant effect prediction refers to predicting how amino acid mutations in a protein sequence affect the protein's function, stability, or ability to bind other molecules.76% similarUnverifiedProteinMPNN uses a message-passing neural network to predict the optimal amino acid sequence given a backbone structure, solving the inverse folding problem.71% similarVerifiedCo-folding refers to simultaneously predicting the three-dimensional structures of a protein and a ligand and their binding mode, allowing the protein and ligand to mutually adapt (induced fit effect).70% similarUnverifiedProtein inverse folding refers to designing amino acid sequences that fold into a given three-dimensional backbone structure; ProteinMPNN and ESM-IF are representative tools.70% similar
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