Unverified50% confidenceFactExact time
In 1986, Henry B. Cogon revealed the nonlinear effect, demonstrating that an initial deviation so small it is almost negligible can be amplified in the reaction far beyond expectations, and that product purity can be higher than catalyst purity.
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Long-term
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10/12/2026
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Related Claims
UnverifiedHenri B. Kagan revealed a nonlinear effect: under certain conditions, a tiny difference in catalyst chirality can have a huge impact on the proportion of enantiomers in the product.73% similarUnverifiedIn 1986, Kagan's team reported three reactions and found that the relationship between catalyst purity and product purity was not linear but curved—sometimes a catalyst of only half purity could produce a product of far higher purity, which is known as the nonlinear effect.70% similarUnverifiedIn 1986, Kagan published findings on nonlinear effects, discovering that product ratios do not change linearly with the catalyst but follow a curve, which can significantly increase the proportion of the target mirror-image molecule.69% similarUnverifiedSoai discovered the asymmetric autocatalytic reaction—the product itself can catalyze its own formation, achieving a chiral amplification effect, such that even if the ratio of the two enantiomers deviates only slightly at the start, the reaction can spontaneously amplify the deviation to nearly a single enantiomer.62% similarUnverifiedKagan confirmed the positive nonlinear effect model through experiments such as the Sharpless oxidation reaction, with the measured curves clearly deviating from the expected straight line.61% similar
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