Unverified50% confidenceFactExact time
Traditional asymmetric catalysis theory holds that the chiral purity of the catalyst and the enantiomeric excess (ee value) of the product are related linearly.
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10/12/2026
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Related Claims
UnverifiedIn 1986, Kagan's team reported three reactions and found that the relationship between catalyst purity and product purity was not linear but curved—sometimes a catalyst of only half purity could produce a product of far higher purity, which is known as the nonlinear effect.68% similarUnverifiedKagan challenged the dogma that the ratio of product enantiomers is linearly related to the ratio of the catalyst, proposing that two or more chiral ligands can simultaneously bind to the metal center of a catalyst.68% similarUnverifiedAutocatalysis and nonlinear effects often appear together, jointly forming the chemical basis of chiral amplification.68% similarUnverifiedKagan and Soai were recognized for the discovery of nonlinear effects and autocatalysis in asymmetric organic synthesis.67% similarUnverifiedHenri B. Kagan revealed a nonlinear effect: under certain conditions, a tiny difference in catalyst chirality can have a huge impact on the proportion of enantiomers in the product.66% similar
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